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Does Testosterone Interact with Oxymetazoline?

Testosterone and Oxymetazoline have a minor drug interaction according to U.S. FDA drug labeling data. Oxymetazoline decreased mean AUC and Cmax of total testosterone by 2.6% and 3.6% respectively when given 30 minutes prior to testosterone; no clinically significant impact on absorption. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Minor
Testosterone Class
Androgen
Management
Generally manageable
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Testosterone and your doctor is considering prescribing Oxymetazoline (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Testosterone(Fortesta)+💊 Oxymetazoline(Sinufrin Plus)

Severity & Interaction Details

✅
minor
Generally safe — minor interaction
Low clinical significance. Routine awareness is usually sufficient.
Severity scale
MinorContra
On record
Yes
Drug A class
Androgen
Drug B class
—
Source
NLP:testosterone

What this means in plain English

Oxymetazoline decreased mean AUC and Cmax of total testosterone by 2.6% and 3.6% respectively when given 30 minutes prior to testosterone; no clinically significant impact on absorption.

About Testosterone and Oxymetazoline

Testosterone is an Androgen. You may recognize them by the brand names Fortesta and Sinufrin Plus. Testosterone is applied to the skin. Testosterone additionally carries an FDA boxed warning, the FDA's strongest safety alert.

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.