Does Theophylline Interact with Nicotine?
CDI records a moderate classification for Theophylline and Nicotine. The stored summary is: Smoking cessation with nicotine replacement may require dose decrease due to deinduction of hepatic enzymes. The mechanism involves deinduction of hepatic enzymes on smoking cessation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Theophylline Class
- Methylxanthine
- Nicotine Class
- Cholinergic Nicotinic Agonist
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Deinduction of hepatic enzymes on smoking cessation
What To Tell Your Doctor or Pharmacist
If you are taking Theophylline and your doctor is considering prescribing Nicotine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider