Does Theophylline Interact with Probenecid And Colchicine?
Theophylline and Probenecid And Colchicine have a minor drug interaction according to U.S. FDA drug labeling data. Falsely high readings for theophylline reported in vitro when therapeutic concentrations combined with probenecid using Schack and Waxler technique. The mechanism involves in vitro interference with laboratory measurement. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Theophylline Class
- Methylxanthine
- Probenecid And Colchicine Class
- Alkaloid
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Theophylline and Probenecid And Colchicine occurs because in vitro interference with laboratory measurement. Clinically, this means falsely high readings for theophylline reported in vitro when therapeutic concentrations combined with probenecid using schack and waxler technique. This is classified as a minor interaction with generally low clinical significance, though your healthcare provider should still be informed that you are taking both medications.
What To Tell Your Doctor or Pharmacist
If you are taking Theophylline and your doctor is considering prescribing Probenecid And Colchicine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider