Does Thioridazine Interact with Metoprolol Tartrate And Hydrochlorothiazide?
CDI records a moderate classification for Thioridazine and Metoprolol Tartrate And Hydrochlorothiazide. The stored summary is: Potent CYP2D6 inhibitor may increase plasma concentration of metoprolol; caution should be exercised. The mechanism involves cyp2d6 inhibition increases metoprolol levels. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Metoprolol Tartrate And Hydrochlorothiazide Class
- Thiazide Diuretic
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP2D6 inhibition increases metoprolol levels
What To Tell Your Doctor or Pharmacist
If you are taking Thioridazine and your doctor is considering prescribing Metoprolol Tartrate And Hydrochlorothiazide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider