Does Thyroid Hormones Interact with Estradiol?
Moderate interaction. Estradiol increases thyroid-binding globulin, which may increase circulating total thyroid hormone levels. Patients on thyroid replacement therapy may require higher doses.
Source & how this summary was prepared
This interaction summary was extracted from FDA drug labeling through openFDA, using automated processing and AI assistance. NIH/NLM RxNorm helps organize drug names.
Read the saved source label on DailyMed →
A separate current-label comparison has not been recorded for this page. Read about our extraction process.
- Interaction classification
- Moderate
- Estradiol Class
- Estrogen
- Management
- Confirm exact products with your pharmacist
- Data Source
- U.S. FDA via OpenFDA
How this interaction works
Increased thyroid-binding globulin (TBG) leading to increased circulating total thyroid hormone
What To Tell Your Doctor or Pharmacist
If you are taking Thyroid Hormones and your doctor is considering prescribing Estradiol (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider