Does Tinidazole Interact with Fluorouracil?
CDI records a moderate classification for Tinidazole and Fluorouracil. The stored summary is: Tinidazole may decrease the clearance of fluorouracil. Monitor for fluorouracil-associated toxicities. The mechanism involves decreased clearance of fluorouracil. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Tinidazole Class
- Nitroimidazole Antimicrobial
- Fluorouracil Class
- Nucleoside Metabolic Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Decreased clearance of fluorouracil
What To Tell Your Doctor or Pharmacist
If you are taking Tinidazole and your doctor is considering prescribing Fluorouracil (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider