Does Tipranavir Interact with Omeprazole?
Tipranavir and Omeprazole have a moderate drug interaction according to U.S. FDA drug labeling data. Probe substrate for CYP2C19; modest inhibition at first dose but marked induction at steady state with APTIVUS/ritonavir; may require monitoring. The mechanism involves cyp2c19 inhibition then induction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Tipranavir Class
- Protease Inhibitor
- Omeprazole Class
- Proton Pump Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Tipranavir and Omeprazole occurs because cyp2c19 inhibition then induction. Clinically, this means probe substrate for cyp2c19; modest inhibition at first dose but marked induction at steady state with aptivus/ritonavir; may require monitoring. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Tipranavir and your doctor is considering prescribing Omeprazole (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider