Does Tobramycin Inhalation Solution Interact with Furosemide?
CDI records a contraindicated classification for Tobramycin Inhalation Solution and Furosemide. The stored summary is: Should not be administered concomitantly; diuretics can enhance aminoglycoside toxicity by altering antibiotic concentrations in serum and tissue. The mechanism involves enhanced aminoglycoside toxicity through altered serum and tissue antibiotic concentrations. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
Evidence status
A current label comparison is not yet available for this record. The summary and severity are stored CDI information; they have not been independently validated on this page against the exact product label.
Confirm the medicine, formulation, route, and applicable warning with your pharmacist or prescriber. Independent clinical review has not been recorded.
- Stored CDI classification
- Contraindicated
- Tobramycin Inhalation Solution Class
- Aminoglycoside Antibacterial
- Furosemide Class
- Loop Diuretic
- Management
- Confirm exact products with your pharmacist
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Enhanced aminoglycoside toxicity through altered serum and tissue antibiotic concentrations
What To Tell Your Doctor or Pharmacist
If you are taking Tobramycin Inhalation Solution and your doctor is considering prescribing Furosemide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider