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Does Tocilizumab Interact with Methotrexate?

Tocilizumab and Methotrexate have a minor drug interaction according to U.S. FDA drug labeling data. Concomitant administration with tocilizumab had no clinically significant effect on methotrexate exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Minor
Tocilizumab Class
Interleukin-6 Receptor Antagonist
Methotrexate Class
Folate Analog Metabolic Inhibitor
Management
Generally manageable
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Tocilizumab and your doctor is considering prescribing Methotrexate (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Tocilizumab(Tyenne)+💊 Methotrexate(Otrexup)

Severity & Interaction Details

✅
minor
Generally safe — minor interaction
Low clinical significance. Routine awareness is usually sufficient.
Severity scale
MinorContra
On record
Yes
Drug A class
Interleukin-6 Receptor Antagonist
Drug B class
Folate Analog Metabolic Inhibitor
Source
NLP:tocilizumab

What this means in plain English

Concomitant administration with tocilizumab had no clinically significant effect on methotrexate exposure.

About Tocilizumab and Methotrexate

Tocilizumab is an Interleukin-6 Receptor Antagonist, while Methotrexate is a Folate Analog Metabolic Inhibitor. You may recognize them by the brand names Tyenne and Otrexup. Tocilizumab is given by intravenous (IV) infusion, whereas Methotrexate is given by intramuscular injection. Both Tocilizumab and Methotrexate carry an FDA boxed warning — the agency's most serious safety designation.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.