Topotecan + Cisplatin Interaction
Majorinteraction on record
Description
Combination causes severe myelosuppression with sequence-dependent interaction. At 1.25 mg/m² topotecan with 50 mg/m² cisplatin, severe neutropenia and neutropenic sepsis were reported. Dose reduction required.
Mechanism
Myelosuppression; sequence-dependent interaction affecting severity based on administration timing
Source: NLP:topotecan