Does Triamterene Interact with Fosinopril Sodium?
Triamterene and Fosinopril Sodium have a moderate drug interaction according to U.S. FDA drug labeling data. Potassium-sparing diuretic that can increase risk of hyperkalemia when combined with fosinopril. Serum potassium should be monitored frequently. The mechanism involves fosinopril reduces potassium loss; triamterene increases potassium retention. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Triamterene Class
- Potassium-sparing Diuretic
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Triamterene and Fosinopril Sodium occurs because fosinopril reduces potassium loss; triamterene increases potassium retention. Clinically, this means potassium-sparing diuretic that can increase risk of hyperkalemia when combined with fosinopril. serum potassium should be monitored frequently. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Triamterene and your doctor is considering prescribing Fosinopril Sodium (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider