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Does Triamterene Interact with Dofetilide?

Triamterene and Dofetilide have a contraindicated drug interaction according to U.S. FDA drug labeling data. Triamterene in combination with HCTZ increases dofetilide AUC by 30%, Cmax by 16%, with pharmacodynamic effects increased by 190% (QTc increase over time). Concomitant use is contraindicated. The mechanism involves increased exposure and potassium effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Triamterene Class
Potassium-sparing Diuretic
Dofetilide Class
Antiarrhythmic
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Triamterene and Dofetilide occurs because increased exposure and potassium effects. Clinically, this means triamterene in combination with hctz increases dofetilide auc by 30%, cmax by 16%, with pharmacodynamic effects increased by 190% (qtc increase over time). concomitant use is contraindicated. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Triamterene and your doctor is considering prescribing Dofetilide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Triamterene(Triamterene)+💊 Dofetilide(Dofetilide)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Potassium-sparing Diuretic
Drug B class
Antiarrhythmic
Source
NLP:dofetilide

What this means in plain English

Triamterene in combination with HCTZ increases dofetilide AUC by 30%, Cmax by 16%, with pharmacodynamic effects increased by 190% (QTc increase over time). Concomitant use is contraindicated.

What the FDA label says

"Increased exposure and potassium effects"

📖 Source: NLP:dofetilide

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.