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Does Triamterene Interact with Valsartan And Hydrochlorothiazide?

Triamterene and Valsartan And Hydrochlorothiazide have a major drug interaction according to U.S. FDA drug labeling data. Potassium-sparing diuretic may lead to increases in serum potassium and in heart failure patients to increases in serum creatinine when used with valsartan. The mechanism involves both agents block renin-angiotensin system and increase serum potassium. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Triamterene Class
Potassium-sparing Diuretic
Valsartan And Hydrochlorothiazide Class
Angiotensin 2 Receptor Blocker
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Triamterene and Valsartan And Hydrochlorothiazide occurs because both agents block renin-angiotensin system and increase serum potassium. Clinically, this means potassium-sparing diuretic may lead to increases in serum potassium and in heart failure patients to increases in serum creatinine when used with valsartan. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Triamterene and your doctor is considering prescribing Valsartan And Hydrochlorothiazide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Triamterene(Triamterene)+💊 Valsartan And Hydrochlorothiazide(Valsartan And Hydrochlorothiazide)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Potassium-sparing Diuretic
Drug B class
Angiotensin 2 Receptor Blocker
Source
NLP:valsartan and hydrochlorothiazide

What this means in plain English

Potassium-sparing diuretic may lead to increases in serum potassium and in heart failure patients to increases in serum creatinine when used with valsartan.

What the FDA label says

"Both agents block renin-angiotensin system and increase serum potassium"

📖 Source: NLP:valsartan and hydrochlorothiazide

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.