Trimipramine + Fluoxetine Interaction
Majorinteraction on record
Description
Fluoxetine inhibits P450 2D6, potentially increasing trimipramine plasma concentrations and causing toxicity. Sufficient time must elapse when switching from fluoxetine to trimipramine due to fluoxetine's long half-life.
Mechanism
Inhibition of cytochrome P450 2D6 metabolism
Source: NLP:trimipramine