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Does Valganciclovir Hydrochloride Interact with Imipenem And Cilastatin?

Valganciclovir Hydrochloride and Imipenem And Cilastatin have a contraindicated drug interaction according to U.S. FDA drug labeling data. Generalized seizures have been reported in patients receiving ganciclovir and imipenem-cilastatin. Coadministration is not recommended. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Imipenem And Cilastatin Class
Penem Antibacterial
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Valganciclovir Hydrochloride and your doctor is considering prescribing Imipenem And Cilastatin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Valganciclovir Hydrochloride(Valganciclovir Hydrochloride For Oral)+💊 Imipenem And Cilastatin(Primaxin)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Penem Antibacterial
Source
NLP:valganciclovir hydrochloride

What this means in plain English

Generalized seizures have been reported in patients receiving ganciclovir and imipenem-cilastatin. Coadministration is not recommended.

About Valganciclovir Hydrochloride and Imipenem And Cilastatin

Imipenem And Cilastatin is a Penem Antibacterial. Imipenem And Cilastatin is also sold under the brand name Primaxin. Valganciclovir Hydrochloride is taken by mouth, whereas Imipenem And Cilastatin is given by intravenous (IV) infusion. Valganciclovir Hydrochloride additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.