Valproate + Tiagabine Hydrochloride Interaction
Moderateinteraction on record
Description
Tiagabine causes slight decrease (about 10%) in steady-state valproate concentrations. Valproate significantly decreases tiagabine binding in vitro, resulting in approximately 40% increase in free tiagabine concentration.
Mechanism
Valproate decreases tiagabine protein binding
Source: NLP:tiagabine hydrochloride