Does Valproic Acid Interact with Imipenem And Cilastatin?
CDI records a major classification for Valproic Acid and Imipenem And Cilastatin. The stored summary is: Co-administration reduces valproic acid concentrations below therapeutic range, increasing risk of breakthrough seizures. Generally not recommended. The mechanism involves may inhibit hydrolysis of valproic acid's glucuronide metabolite back to valproic acid. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Valproic Acid Class
- Anti-epileptic Agent
- Imipenem And Cilastatin Class
- Penem Antibacterial
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
May inhibit hydrolysis of valproic acid's glucuronide metabolite back to valproic acid
What To Tell Your Doctor or Pharmacist
If you are taking Valproic Acid and your doctor is considering prescribing Imipenem And Cilastatin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider