Does Valproic Acid Interact with Meropenem And Sodium Chloride?
CDI records a major classification for Valproic Acid and Meropenem And Sodium Chloride. The stored summary is: Co-administration may reduce valproic acid concentrations below therapeutic range, increasing risk of breakthrough seizures. Mechanism may involve carbapenem inhibition of valproic acid glucuronide metabolite hydrolysis. The mechanism involves possible inhibition of hydrolysis of valproic acid's glucuronide metabolite back to valproic acid. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Valproic Acid Class
- Anti-epileptic Agent
- Meropenem And Sodium Chloride Class
- beta Lactamase Inhibitor
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Possible inhibition of hydrolysis of valproic acid's glucuronide metabolite back to valproic acid
What To Tell Your Doctor or Pharmacist
If you are taking Valproic Acid and your doctor is considering prescribing Meropenem And Sodium Chloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider