Does Valproic Acid Interact with Oxycodone And Aspirin?
CDI records a moderate classification for Valproic Acid and Oxycodone And Aspirin. The stored summary is: Salicylate can displace protein-bound valproic acid, increasing serum valproic acid levels. The mechanism involves protein binding displacement. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Valproic Acid Class
- Anti-epileptic Agent
- Oxycodone And Aspirin Class
- Nonsteroidal Anti-inflammatory Drug
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Protein binding displacement
What To Tell Your Doctor or Pharmacist
If you are taking Valproic Acid and your doctor is considering prescribing Oxycodone And Aspirin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider