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Does Valproic Acid Interact with Vorinostat?

Valproic Acid and Vorinostat have a major drug interaction according to U.S. FDA drug labeling data. Severe thrombocytopenia and gastrointestinal bleeding reported with concomitant use of VORINOSTAT and other HDAC inhibitors. Monitor platelet count every 2 weeks for first 2 months. The mechanism involves hdac inhibitor interaction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Valproic Acid Class
Anti-epileptic Agent
Vorinostat Class
Histone Deacetylase Inhibitor
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Valproic Acid and Vorinostat occurs because hdac inhibitor interaction. Clinically, this means severe thrombocytopenia and gastrointestinal bleeding reported with concomitant use of vorinostat and other hdac inhibitors. monitor platelet count every 2 weeks for first 2 months. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Valproic Acid and your doctor is considering prescribing Vorinostat (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Valproic Acid(Valproic Acid)+💊 Vorinostat(Zolinza)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Anti-epileptic Agent
Drug B class
Histone Deacetylase Inhibitor
Source
NLP:vorinostat

What this means in plain English

Severe thrombocytopenia and gastrointestinal bleeding reported with concomitant use of VORINOSTAT and other HDAC inhibitors. Monitor platelet count every 2 weeks for first 2 months.

What the FDA label says

"HDAC inhibitor interaction"

📖 Source: NLP:vorinostat

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.