Does Vandetanib Interact with Dapagliflozin And Metformin Hydrochloride?
CDI records a major classification for Vandetanib and Dapagliflozin And Metformin Hydrochloride. The stored summary is: OCT2/MATE inhibitor that increases metformin exposure and may increase risk for lactic acidosis. The mechanism involves interference with renal tubular transport of metformin. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Vandetanib Class
- Kinase Inhibitor
- Dapagliflozin And Metformin Hydrochloride Class
- Sodium-Glucose Cotransporter 2 Inhibitor
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Interference with renal tubular transport of metformin
What To Tell Your Doctor or Pharmacist
If you are taking Vandetanib and your doctor is considering prescribing Dapagliflozin And Metformin Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider