Does Warfarin Interact with Ethacrynic Acid?
CDI records a moderate classification for Warfarin and Ethacrynic Acid. The stored summary is: Ethacrynic acid may displace warfarin from plasma protein binding; reduction in anticoagulant dosage may be required. The mechanism involves plasma protein binding displacement. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Ethacrynic Acid Class
- Loop Diuretic
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Plasma protein binding displacement
What To Tell Your Doctor or Pharmacist
If you are taking Warfarin and your doctor is considering prescribing Ethacrynic Acid (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider