Does Warfarin Interact with Nevirapine?
CDI records a major classification for Warfarin and Nevirapine. The stored summary is: Plasma warfarin levels may change with potential for increases in coagulation time. Anticoagulation levels should be monitored frequently. The mechanism involves complex in vitro interaction affecting warfarin metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Nevirapine Class
- Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Complex in vitro interaction affecting warfarin metabolism
What To Tell Your Doctor or Pharmacist
If you are taking Warfarin and your doctor is considering prescribing Nevirapine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider