Does Warfarin Interact with Tolcapone?
Warfarin and Tolcapone have a moderate drug interaction according to U.S. FDA drug labeling data. Tolcapone has affinity for CYP450 2C9 in vitro and may interfere with warfarin clearance. Clinical information is limited; coagulation parameters should be monitored when co-administered. The mechanism involves cyp450 2c9 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Tolcapone Class
- Catechol-O-Methyltransferase Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Warfarin and Tolcapone occurs because cyp450 2c9 inhibition. Clinically, this means tolcapone has affinity for cyp450 2c9 in vitro and may interfere with warfarin clearance. clinical information is limited; coagulation parameters should be monitored when co-administered. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Warfarin and your doctor is considering prescribing Tolcapone (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider