Does Levodopa Interact with Tolcapone?
CDI records a moderate classification for Levodopa and Tolcapone. The stored summary is: When combined with tolcapone and desipramine, frequency of adverse events increased slightly. Caution advised due to additive effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Levodopa Class
- Aromatic Amino Acid
- Tolcapone Class
- Catechol-O-Methyltransferase Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Levodopa and your doctor is considering prescribing Tolcapone (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider