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Does Yellow Fever Vaccine Interact with Tuberculin Purified Protein Derivative?

Yellow Fever Vaccine and Tuberculin Purified Protein Derivative have a moderate drug interaction according to U.S. FDA drug labeling data. Live yellow fever vaccine may temporarily depress PPD reactivity. Tuberculin test should be given before vaccine, simultaneously at separate site, or postponed 4-6 weeks. The mechanism involves live virus vaccine interference. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Tuberculin Purified Protein Derivative Class
Skin Test Antigen
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Yellow Fever Vaccine and Tuberculin Purified Protein Derivative occurs because live virus vaccine interference. Clinically, this means live yellow fever vaccine may temporarily depress ppd reactivity. tuberculin test should be given before vaccine, simultaneously at separate site, or postponed 4-6 weeks. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Yellow Fever Vaccine and your doctor is considering prescribing Tuberculin Purified Protein Derivative (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Yellow Fever Vaccine+💊 Tuberculin Purified Protein Derivative(Tubersol)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Skin Test Antigen
Source
NLP:tuberculin purified protein derivative

What this means in plain English

Live yellow fever vaccine may temporarily depress PPD reactivity. Tuberculin test should be given before vaccine, simultaneously at separate site, or postponed 4-6 weeks.

What the FDA label says

"Live virus vaccine interference"

📖 Source: NLP:tuberculin purified protein derivative

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.