Zongertinib + Cyp3a Inducers Interaction
Majorinteraction on record
Description
Strong CYP3A4 inducers decrease zongertinib exposure, which may reduce effectiveness of HERNEXEOS. Avoid concomitant use; if unavoidable, increase HERNEXEOS dose.
Mechanism
CYP3A4-mediated metabolism; zongertinib is a CYP3A substrate
Source: NLP:zongertinib