Angiotensin II Receptor Blockers (ARBs)

ARBs treat high blood pressure and heart failure by blocking angiotensin II. They interact with NSAIDs, potassium-sparing diuretics, lithium, and ACE inhibitors.

11 drugs in this class6 notable interactions shown

ARBs Drugs (11)

Amlodipine And ValsartanExforge IrbesartanAvapro Irbesartan And HydrochlorothiazideAvalide Sacubitril And ValsartanEntresto SparsentanFilspari TelmisartanTwynsta Telmisartan And AmlodipineTwynsta Telmisartan And HydrochlorothiazideMicardis-HCT Telmisartan, Amlodipine And IndapamideWidaplik ValsartanExforge HCT Valsartan And HydrochlorothiazideExforge HCT

Notable ARBs Interactions

Amlodipine And Valsartan + Aliskiren⚠️Major

Dual blockade of the renin-angiotensin system is associated with increased risks of hypotension, hyperkalemia, and changes in renal function.

Amlodipine And Valsartan + Angiotensin Ii⚠️Major

Dual blockade of RAS with valsartan and other ARBs is associated with increased risks of hypotension, hyperkalemia, and changes in renal function including acute renal failure.

Amlodipine And Valsartan + Aspirin⚠️Major

In elderly, volume-depleted, or renally impaired patients, coadministration may result in deterioration of renal function including possible acute renal failure. NSAIDs may attenuate antihypertensive effect. Monitor renal function.

Irbesartan + Aliskiren⛔Contraindicated

Dual RAS blockade is contraindicated in patients with diabetes. Avoid in patients with renal impairment (GFR <60 mL/min). Associated with increased risks of hypotension, hyperkalemia, and acute renal failure.

Irbesartan + Agents Increasing Serum Potassium⚠️Major

Coadministration of irbesartan with drugs that raise serum potassium levels may result in hyperkalemia, sometimes severe.

Irbesartan + Angiotensin Ii⚠️Major

Dual blockade of the RAS associated with increased risks of hypotension, hyperkalemia, and changes in renal function including acute renal failure. Avoid combined use.

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.