Angiotensin II Receptor Blockers (ARBs)

ARBs treat high blood pressure and heart failure by blocking angiotensin II. They interact with NSAIDs, potassium-sparing diuretics, lithium, and ACE inhibitors.

11 drugs in this class6 notable interactions shown

ARBs Drugs (11)

Amlodipine And ValsartanAmlodipine And Valsartan Irbesartan Irbesartan And HydrochlorothiazideAvalide Sacubitril And ValsartanSacubitril And Valsartan SparsentanFilspari Telmisartan Telmisartan And AmlodipineTelmisartan And Amlodipine Telmisartan And HydrochlorothiazideTelmisartan And Hydrochlorothiazide Telmisartan, Amlodipine And IndapamideWidaplik Valsartan Valsartan And HydrochlorothiazideValsartan And Hydrochlorothiazide

Notable ARBs Interactions

Amlodipine And Valsartan + Aliskiren⚠️Major

Dual blockade of the renin-angiotensin system is associated with increased risks of hypotension, hyperkalemia, and changes in renal function.

Amlodipine And Valsartan + Angiotensin Ii⚠️Major

Dual blockade of RAS with valsartan and other ARBs is associated with increased risks of hypotension, hyperkalemia, and changes in renal function including acute renal failure.

Amlodipine And Valsartan + Lithium⚠️Major

Increases in serum lithium levels and potential lithium toxicity may occur with valsartan.

Irbesartan + Aliskiren⛔Contraindicated

Dual RAS blockade is contraindicated in patients with diabetes. Avoid in patients with renal impairment (GFR <60 mL/min). Associated with increased risks of hypotension, hyperkalemia, and acute renal failure.

Irbesartan + Agents Increasing Serum Potassium⚠️Major

Coadministration of irbesartan with drugs that raise serum potassium levels may result in hyperkalemia, sometimes severe.

Irbesartan + Angiotensin Ii⚠️Major

Dual blockade of the RAS associated with increased risks of hypotension, hyperkalemia, and changes in renal function including acute renal failure. Avoid combined use.

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.