Tramadol Interactions

Serious, sometimes fatal reactions reported with concomitant use of opioid drugs and MAOIs, including selective MAO-B inhibitors.

Source: NLP:safinamide mesylate

Concomitant use increases risk of respiratory depression due to actions at different CNS receptor sites.

Source: NLP:alprazolam

Postmarketing cases of serotonin syndrome reported; tricyclic antidepressants may enhance seizure risk.

Source: NLP:cyclobenzaprine

Serotonin syndrome reported; seizure risk may be enhanced.

Source: NLP:cyclobenzaprine hydrochloride

Serotonergic drug that increases risk of serotonin syndrome when combined with amphetamines. Initiate with lower doses and monitor for serotonin syndrome signs.

Source: NLP:dextroamphetamine saccharate, amphetamine aspartate monohydrate, dextroamphetamine sulfate, and amphetamine sulfate

Serotonergic drug increasing risk of serotonin syndrome with dextroamphetamine sulfate.

Source: NLP:dextroamphetamine sulfate

Concomitant use may result in serotonin syndrome. Frequently evaluate patient during treatment initiation and dose adjustment.

Source: NLP:hydromorphone hydrochloride

Concomitant use has resulted in serotonin syndrome.

Source: NLP:levorphanol tartrate

Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modification; discontinue metaxalone if serotonin syndrome occurs.

Source: NLP:metaxalone

Concomitant use increases risk of serotonin syndrome. Monitor for signs and symptoms, particularly during initiation and dose increases.

Source: NLP:mirtazapine

Concomitant use can result in serotonin syndrome. Requires frequent patient evaluation, particularly during initiation and dose adjustment.

Source: NLP:morphine sulfate

Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dose adjustment.

Source: NLP:nalbuphine hydrochloride

Serotonergic drug that may result in serotonin syndrome when used concomitantly.

Source: NLP:oxymorphone hydrochloride

Concomitant use increases risk of serotonin syndrome.

Source: NLP:paroxetine

Concomitant use has resulted in serotonin syndrome. Carefully observe patient during treatment initiation and dose adjustment.

Source: NLP:pentazocine and naloxone

Concomitant use may result in serotonin syndrome.

Source: NLP:remifentanil hydrochloride

Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms, particularly during treatment initiation and dosage increases.

Source: NLP:sertraline hydrochloride

Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms during trazodone initiation.

Source: NLP:trazodone hydrochloride

Potential for serotonin syndrome with serotonergic drug tramadol. Careful patient observation advised.

Source: NLP:venlafaxine

Potential for serotonin syndrome when used with serotonergic drugs. Careful patient observation advised.

Source: NLP:venlafaxine hydrochloride, extended release

Potential for serotonin syndrome when combined with serotonergic drugs. Careful patient observation advised.

Source: NLP:venlafaxine hydrochloride

Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syndrome occurs.

Source: NLP:desvenlafaxine er

Ondansetron may increase patient-controlled administration of tramadol. Monitor patients to ensure adequate pain control.

Source: NLP:ondansetron

Ondansetron may increase patient-controlled administration of tramadol. Monitor patients to ensure adequate pain control.

Source: NLP:ondansetron hydrochloride

When used together, ondansetron may increase patient-controlled administration of tramadol. Monitor patients to ensure adequate pain control.

Source: NLP:ondansetron tablets

Caution advised due to potential for serotonin syndrome when coadministered with paroxetine.

Source: NLP:paroxetine hydrochloride hemihydrate

Concomitant use of tramadol and sertraline increases the risk of serotonin syndrome; monitor patients for signs and symptoms.

Source: NLP:sertraline

Serotonergic drug may increase risk of serotonin syndrome; requires frequent patient evaluation.

Source: NLP:tapentadol hydrochloride