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Tramadol

40 interactions on record

Tramadol has 40 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 29 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Safinamide Mesylate, Selegiline Hydrochloride, Alprazolam. Patients taking Tramadol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 40
Contraindicated: 2
Major: 29
Moderate: 9

Contraindicated (2)

Tramadol + Safinamide Mesylate— Serious, sometimes fatal reactions reported with concomitant use of opioid drugs and MAOIs, including selective MAO-B in…
Tramadol + Selegiline Hydrochloride— Serious, sometimes fatal reactions reported with concomitant use of tramadol and MAOIs including selective MAO-B inhibit…

Major (29)

Tramadol + Alprazolam— Concomitant use increases risk of respiratory depression due to actions at different CNS receptor sites.
Tramadol + Alprazolam C-Iv— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
Tramadol + Amphetamine Sulfate— Serotonergic drug that increases risk of serotonin syndrome when used concomitantly with amphetamine sulfate.
Tramadol + Atropa Belladonna And Opium— Concomitant use may result in serotonin syndrome. Patient requires careful observation, particularly during initiation a…
Tramadol + Cyclobenzaprine— Postmarketing cases of serotonin syndrome reported; tricyclic antidepressants may enhance seizure risk.
Tramadol + Cyclobenzaprine Hcl Er— May enhance seizure risk and serotonin syndrome has been reported during combined use.
Tramadol + Cyclobenzaprine Hydrochloride— Serotonin syndrome reported; seizure risk may be enhanced.
Tramadol + Desvenlafaxine Succinate— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
Tramadol + Dextroamphetamine— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and discontinue if serotonin syndrome occurs.
Tramadol + Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate— Serotonergic drug that increases risk of serotonin syndrome when combined with amphetamines. Initiate with lower doses a…
Tramadol + Dextroamphetamine Sulfate— Serotonergic drug increasing risk of serotonin syndrome with dextroamphetamine sulfate.
Tramadol + Hydrocodone Bitartrate And Acetaminophen— Concomitant use has resulted in serotonin syndrome; carefully observe patient during treatment initiation and dose adjus…
Tramadol + Hydromorphone Hydrochloride— Concomitant use may result in serotonin syndrome. Frequently evaluate patient during treatment initiation and dose adjus…
Tramadol + Levorphanol Tartrate— Concomitant use has resulted in serotonin syndrome.
Tramadol + Metaxalone— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modif…
Tramadol + Mirtazapine— Concomitant use increases risk of serotonin syndrome. Monitor for signs and symptoms, particularly during initiation and…
Tramadol + Morphine Sulfate— Concomitant use can result in serotonin syndrome. Requires frequent patient evaluation, particularly during initiation a…
Tramadol + Nalbuphine Hydrochloride— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dose adjustm…
Tramadol + Oxymorphone Hydrochloride— Serotonergic drug that may result in serotonin syndrome when used concomitantly.
Tramadol + Paroxetine— Concomitant use increases risk of serotonin syndrome.
Tramadol + Pentazocine Hydrochloride And Naloxone Hydrochloride— Concomitant use has resulted in serotonin syndrome. Carefully observe patient during treatment initiation and dose adjus…
Tramadol + Remifentanil Hydrochloride— Concomitant use may result in serotonin syndrome.
Tramadol + Sertraline— Concomitant use of tramadol with sertraline increases the risk of serotonin syndrome. Monitor patients for signs and sym…
Tramadol + Sertraline Hydrochloride— Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms, particularly during treat…
Tramadol + Tapentadol Hydrochloride— Concomitant use may result in serotonin syndrome. Frequent patient evaluation is recommended during initiation and dose …
Tramadol + Trazodone Hydrochloride— Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms during trazodone initiatio…
Tramadol + Venlafaxine— Potential for serotonin syndrome with serotonergic drug tramadol. Careful patient observation advised.
Tramadol + Venlafaxine Hcl Er— Potential for serotonin syndrome when used with serotonergic drugs. Careful patient observation advised.
Tramadol + Venlafaxine Hydrochloride— Potential for serotonin syndrome when combined with serotonergic drugs. Careful patient observation advised.

Moderate (9)

Tramadol + Butorphanol Tartrate— Concomitant use may result in serotonin syndrome; monitor regularly during initiation and dose adjustment.
Tramadol + Citalopram Hydrobromide— Potential for serotonin syndrome. Caution advised when coadministered with citalopram.
Tramadol + Desvenlafaxine— Concomitant use increases risk of serotonin syndrome. Monitor for serotonin syndrome symptoms; consider discontinuation …
Tramadol + Desvenlafaxine Er— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
Tramadol + Ondansetron— Ondansetron may increase patient-controlled administration of tramadol. Monitor patients to ensure adequate pain control…
Tramadol + Ondansetron Hydrochloride— Ondansetron may increase patient-controlled administration of tramadol. Monitor patients to ensure adequate pain control…
Tramadol + Ondansetron Tablets— When used together, ondansetron may increase patient-controlled administration of tramadol. Monitor patients to ensure a…
Tramadol + Paroxetine Hydrochloride— Caution advised due to potential for serotonin syndrome when coadministered with paroxetine.
Tramadol + Paroxetine Hydrochloride Hemihydrate— Caution advised due to potential for serotonin syndrome when coadministered with paroxetine.

Tramadol + Safinamide Mesylate⛔Contraindicated

Serious, sometimes fatal reactions reported with concomitant use of opioid drugs and MAOIs, including selective MAO-B inhibitors.

Tramadol + Selegiline Hydrochloride⛔Contraindicated

Serious, sometimes fatal reactions reported with concomitant use of tramadol and MAOIs including selective MAO-B inhibitors.

Tramadol + Alprazolam⚠️Major

Concomitant use increases risk of respiratory depression due to actions at different CNS receptor sites.

Tramadol + Alprazolam C-Iv⚠️Major

Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monitor closely for respiratory depression and sedation.

Tramadol + Amphetamine Sulfate⚠️Major

Serotonergic drug that increases risk of serotonin syndrome when used concomitantly with amphetamine sulfate.

Tramadol + Atropa Belladonna And Opium⚠️Major

Concomitant use may result in serotonin syndrome. Patient requires careful observation, particularly during initiation and dose adjustment.

Tramadol + Cyclobenzaprine⚠️Major

Postmarketing cases of serotonin syndrome reported; tricyclic antidepressants may enhance seizure risk.

Tramadol + Cyclobenzaprine Hcl Er⚠️Major

May enhance seizure risk and serotonin syndrome has been reported during combined use.

Tramadol + Cyclobenzaprine Hydrochloride⚠️Major

Serotonin syndrome reported; seizure risk may be enhanced.

Tramadol + Desvenlafaxine Succinate⚠️Major

Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syndrome occurs.

Tramadol + Dextroamphetamine⚠️Major

Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and discontinue if serotonin syndrome occurs.

Tramadol + Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate⚠️Major

Serotonergic drug that increases risk of serotonin syndrome when combined with amphetamines. Initiate with lower doses and monitor for serotonin syndrome signs.

Tramadol + Dextroamphetamine Sulfate⚠️Major

Serotonergic drug increasing risk of serotonin syndrome with dextroamphetamine sulfate.

Tramadol + Hydrocodone Bitartrate And Acetaminophen⚠️Major

Concomitant use has resulted in serotonin syndrome; carefully observe patient during treatment initiation and dose adjustment.

Tramadol + Hydromorphone Hydrochloride⚠️Major

Concomitant use may result in serotonin syndrome. Frequently evaluate patient during treatment initiation and dose adjustment.

Tramadol + Levorphanol Tartrate⚠️Major

Concomitant use has resulted in serotonin syndrome.

Tramadol + Metaxalone⚠️Major

Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modification; discontinue metaxalone if serotonin syndrome occurs.

Tramadol + Mirtazapine⚠️Major

Concomitant use increases risk of serotonin syndrome. Monitor for signs and symptoms, particularly during initiation and dose increases.

Tramadol + Morphine Sulfate⚠️Major

Concomitant use can result in serotonin syndrome. Requires frequent patient evaluation, particularly during initiation and dose adjustment.

Tramadol + Nalbuphine Hydrochloride⚠️Major

Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dose adjustment.

Tramadol + Oxymorphone Hydrochloride⚠️Major

Serotonergic drug that may result in serotonin syndrome when used concomitantly.

Tramadol + Paroxetine⚠️Major

Concomitant use increases risk of serotonin syndrome.

Tramadol + Pentazocine Hydrochloride And Naloxone Hydrochloride⚠️Major

Concomitant use has resulted in serotonin syndrome. Carefully observe patient during treatment initiation and dose adjustment.

Tramadol + Remifentanil Hydrochloride⚠️Major

Concomitant use may result in serotonin syndrome.

Tramadol + Sertraline⚠️Major

Concomitant use of tramadol with sertraline increases the risk of serotonin syndrome. Monitor patients for signs and symptoms.

Tramadol + Sertraline Hydrochloride⚠️Major

Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms, particularly during treatment initiation and dosage increases.

Tramadol + Tapentadol Hydrochloride⚠️Major

Concomitant use may result in serotonin syndrome. Frequent patient evaluation is recommended during initiation and dose adjustment.

Tramadol + Trazodone Hydrochloride⚠️Major

Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms during trazodone initiation.

Tramadol + Venlafaxine⚠️Major

Potential for serotonin syndrome with serotonergic drug tramadol. Careful patient observation advised.

Tramadol + Venlafaxine Hcl Er⚠️Major

Potential for serotonin syndrome when used with serotonergic drugs. Careful patient observation advised.

Tramadol + Venlafaxine Hydrochloride⚠️Major

Potential for serotonin syndrome when combined with serotonergic drugs. Careful patient observation advised.

Tramadol + Butorphanol Tartrate🟡Moderate

Concomitant use may result in serotonin syndrome; monitor regularly during initiation and dose adjustment.

Tramadol + Citalopram Hydrobromide🟡Moderate

Potential for serotonin syndrome. Caution advised when coadministered with citalopram.

Tramadol + Desvenlafaxine🟡Moderate

Concomitant use increases risk of serotonin syndrome. Monitor for serotonin syndrome symptoms; consider discontinuation if it occurs.

Tramadol + Desvenlafaxine Er🟡Moderate

Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syndrome occurs.

Tramadol + Ondansetron🟡Moderate

Ondansetron may increase patient-controlled administration of tramadol. Monitor patients to ensure adequate pain control.

Tramadol + Ondansetron Hydrochloride🟡Moderate

Ondansetron may increase patient-controlled administration of tramadol. Monitor patients to ensure adequate pain control.

Tramadol + Ondansetron Tablets🟡Moderate

When used together, ondansetron may increase patient-controlled administration of tramadol. Monitor patients to ensure adequate pain control.

Tramadol + Paroxetine Hydrochloride🟡Moderate

Caution advised due to potential for serotonin syndrome when coadministered with paroxetine.

Tramadol + Paroxetine Hydrochloride Hemihydrate🟡Moderate

Caution advised due to potential for serotonin syndrome when coadministered with paroxetine.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.