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Does Tramadol Interact with Ondansetron Tablets?

Tramadol and Ondansetron Tablets have a moderate drug interaction according to U.S. FDA drug labeling data. When used together, ondansetron may increase patient-controlled administration of tramadol. Monitor patients to ensure adequate pain control. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Tramadol and your doctor is considering prescribing Ondansetron Tablets (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Tramadol(ConZip)+💊 Ondansetron Tablets(Ondansetron)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:ondansetron tablets

What this means in plain English

When used together, ondansetron may increase patient-controlled administration of tramadol. Monitor patients to ensure adequate pain control.

About Tramadol and Ondansetron Tablets

Tramadol is also sold under the brand name ConZip. Ondansetron Tablets is taken by mouth.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.