Does Tramadol Interact with Hydrocodone Bitartrate And Acetaminophen?
CDI records a major classification for Tramadol and Hydrocodone Bitartrate And Acetaminophen. The stored summary is: Concomitant use has resulted in serotonin syndrome; carefully observe patient during treatment initiation and dose adjustment. The mechanism involves effects on serotonergic neurotransmitter system. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Effects on serotonergic neurotransmitter system
What To Tell Your Doctor or Pharmacist
If you are taking Tramadol and your doctor is considering prescribing Hydrocodone Bitartrate And Acetaminophen (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider