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Vitamin K Antagonists

Check Vitamin K Antagonists Interactions →

4 interactions on record

Vitamin K Antagonists has 4 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Capecitabine, Nilutamide, Pentoxifylline. Patients taking Vitamin K Antagonists should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 4
Major: 3
Moderate: 1

Major (3)

Vitamin K Antagonists + Capecitabine— Capecitabine increases exposure of vitamin K antagonists, which may alter coagulation parameters and/or bleeding, potent…
Vitamin K Antagonists + Nilutamide— Nilutamide inhibits cytochrome P-450 isoenzymes, reducing metabolism of vitamin K antagonists and increasing serum half-…
Vitamin K Antagonists + Pentoxifylline— Increased prothrombin time and increased anticoagulant activity reported. Monitoring of anticoagulant activity recommend…

Moderate (1)

Vitamin K Antagonists + Selumetinib— KOSELUGO capsules contain vitamin E; concomitant use may increase bleeding risk. Monitor for bleeding and increase INR m…

Vitamin K Antagonists + Capecitabine⚠️Major

Capecitabine increases exposure of vitamin K antagonists, which may alter coagulation parameters and/or bleeding, potentially resulting in death. Events may occur within days or up to 1 month after discontinuation.

Vitamin K Antagonists + Nilutamide⚠️Major

Nilutamide inhibits cytochrome P-450 isoenzymes, reducing metabolism of vitamin K antagonists and increasing serum half-life, potentially leading to toxic levels. Prothrombin time should be monitored and dosage may need reduction.

Vitamin K Antagonists + Pentoxifylline⚠️Major

Increased prothrombin time and increased anticoagulant activity reported. Monitoring of anticoagulant activity recommended when pentoxifylline introduced or dose changed.

Vitamin K Antagonists + Selumetinib🟡Moderate

KOSELUGO capsules contain vitamin E; concomitant use may increase bleeding risk. Monitor for bleeding and increase INR monitoring as appropriate.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.