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Does Vitamin K Antagonists Interact with Capecitabine?

Vitamin K Antagonists and Capecitabine have a major drug interaction according to U.S. FDA drug labeling data. Capecitabine increases exposure of vitamin K antagonists, which may alter coagulation parameters and/or bleeding, potentially resulting in death. Events may occur within days or up to 1 month after discontinuation. The mechanism involves increased vitamin k antagonist exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Capecitabine Class
Nucleoside Metabolic Inhibitor
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Vitamin K Antagonists and Capecitabine occurs because increased vitamin k antagonist exposure. Clinically, this means capecitabine increases exposure of vitamin k antagonists, which may alter coagulation parameters and/or bleeding, potentially resulting in death. events may occur within days or up to 1 month after discontinuation. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Vitamin K Antagonists and your doctor is considering prescribing Capecitabine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Vitamin K Antagonists+💊 Capecitabine(Capecitabine)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Nucleoside Metabolic Inhibitor
Source
NLP:capecitabine

What this means in plain English

Capecitabine increases exposure of vitamin K antagonists, which may alter coagulation parameters and/or bleeding, potentially resulting in death. Events may occur within days or up to 1 month after discontinuation.

What the FDA label says

"Increased vitamin K antagonist exposure"

📖 Source: NLP:capecitabine

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.