Vitamin K Antagonists + Nilutamide Interaction
Majorinteraction on record
Description
Nilutamide inhibits cytochrome P-450 isoenzymes, reducing metabolism of vitamin K antagonists and increasing serum half-life, potentially leading to toxic levels. Prothrombin time should be monitored and dosage may need reduction.
Mechanism
Inhibition of hepatic cytochrome P-450 isoenzymes reducing drug metabolism
Source: NLP:nilutamide