Atropine has 13 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Phenylephrine Hydrochloride, Barbiturates, Ephedrine Sulfate. Patients taking Atropine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 13
- Major
- 1
- Moderate
- 12
Major (1)
- Atropine + Phenylephrine Hydrochloride— Agonistic effects increase phenylephrine blood pressure effect.
Moderate (12)
- Atropine + Barbiturates— Atropine may potentiate the effect of barbiturates. Barbiturates should be used cautiously in treating convulsions from …
- Atropine + Ephedrine Sulfate— Augments pressor effect of ephedrine. Carefully monitor blood pressure.
- Atropine + Macimorelin Acetate— Muscarinic antagonist may blunt growth hormone response to MACRILEN and impact diagnostic test accuracy. Avoid concomita…
- Atropine + Morphine Sulfate— Atropine antagonizes morphine respiratory depression.
- Atropine + Nabilone— Additive or super-additive tachycardia and drowsiness reported with concurrent use.
- Atropine + Pilocarpine Hydrchloride— Pilocarpine might antagonize the anticholinergic effects of atropine, potentially reducing its therapeutic efficacy.
- Atropine + Pilocarpine Hydrochloride— Pilocarpine might antagonize the anticholinergic effects of atropine, potentially reducing its therapeutic effect.
- Atropine + Pralidoxime— Pralidoxime may potentiate atropine effect, causing earlier onset of atropinization signs (flushing, mydriasis, tachycar…
- Atropine + Pralidoxime Chloride— Signs of atropinization (flushing, mydriasis, tachycardia, dryness of mouth/nose) may occur earlier than expected, espec…
- Atropine + Pramlintide Acetate— SYMLIN should not be used in patients taking anticholinergic agents that alter gastrointestinal motility. Not studied in…
- Atropine + Trimipramine— Atropine-like anticholinergic effects may be more pronounced when used with trimipramine; particular care should be exer…
- Atropine + Trimipramine Maleate— Atropine-like effects may be more pronounced in patients receiving trimipramine maleate. Particular care should be exerc…