Does Atropine Interact with Pralidoxime Chloride?
CDI records a moderate classification for Atropine and Pralidoxime Chloride. The stored summary is: Signs of atropinization (flushing, mydriasis, tachycardia, dryness of mouth/nose) may occur earlier than expected, especially with large atropine doses or delayed pralidoxime administration. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Atropine Class
- Anticholinergic
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Atropine and your doctor is considering prescribing Pralidoxime Chloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider