Does Atropine Interact with Pilocarpine Hydrchloride?
CDI records a moderate classification for Atropine and Pilocarpine Hydrchloride. The stored summary is: Pilocarpine might antagonize the anticholinergic effects of atropine, potentially reducing its therapeutic efficacy. The mechanism involves pilocarpine antagonizes anticholinergic effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Atropine Class
- Anticholinergic
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Pilocarpine antagonizes anticholinergic effects
What To Tell Your Doctor or Pharmacist
If you are taking Atropine and your doctor is considering prescribing Pilocarpine Hydrchloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider