Does Colesevelam Hydrochloride Interact with Olmesartan Medoxomil Hydrochlorothiazide?
Colesevelam Hydrochloride and Olmesartan Medoxomil Hydrochlorothiazide have a moderate drug interaction according to U.S. FDA drug labeling data. Reduces systemic exposure and peak plasma concentration of olmesartan. Consider administering olmesartan at least 4 hours before colesevelam hydrochloride dose. The mechanism involves bile acid sequestrating agent reduces absorption of olmesartan. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Olmesartan Medoxomil Hydrochlorothiazide Class
- Thiazide Diuretic
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Colesevelam Hydrochloride and Olmesartan Medoxomil Hydrochlorothiazide occurs because bile acid sequestrating agent reduces absorption of olmesartan. Clinically, this means reduces systemic exposure and peak plasma concentration of olmesartan. consider administering olmesartan at least 4 hours before colesevelam hydrochloride dose. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Colesevelam Hydrochloride and your doctor is considering prescribing Olmesartan Medoxomil Hydrochlorothiazide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider