Does Colesevelam Hydrochloride Interact with Olmesartan Medoxomil Hydrochlorothiazide?
CDI records a moderate classification for Colesevelam Hydrochloride and Olmesartan Medoxomil Hydrochlorothiazide. The stored summary is: Reduces systemic exposure and peak plasma concentration of olmesartan. Consider administering olmesartan at least 4 hours before colesevelam hydrochloride dose. The mechanism involves bile acid sequestrating agent reduces absorption of olmesartan. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Olmesartan Medoxomil Hydrochlorothiazide Class
- Thiazide Diuretic
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Bile acid sequestrating agent reduces absorption of olmesartan
What To Tell Your Doctor or Pharmacist
If you are taking Colesevelam Hydrochloride and your doctor is considering prescribing Olmesartan Medoxomil Hydrochlorothiazide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider