Acetaminophen + Isoniazid Interaction
Majorinteraction on record
Description
Isoniazid induces P-450IIE1 enzyme, increasing conversion of acetaminophen to toxic metabolites and potentiating hepatotoxicity. Severe acetaminophen toxicity has been reported.
Mechanism
Induction of hepatic P-450IIE1 mixed-function oxidase enzyme
Source: NLP:isoniazid