Clonidine + Bisoprolol Fumarate And Hydrochlorothiazide Interaction
Majorinteraction on record
Description
Bisoprolol should be discontinued several days before clonidine withdrawal to avoid rebound hypertension and excessive sympathetic reduction.
Mechanism
Additive antihypertensive and sympathetic blocking effects
Source: NLP:bisoprolol fumarate and hydrochlorothiazide