Azelastine Hydrochloride, Fluticasone Propionate has 3 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Ritonavir, Alcohol, Ketoconazole. Patients taking Azelastine Hydrochloride, Fluticasone Propionate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 3
- Contraindicated
- 1
- Major
- 2
Contraindicated (1)
- Azelastine Hydrochloride, Fluticasone Propionate + Ritonavir— Strong CYP3A4 inhibitor that significantly increases fluticasone propionate plasma exposure and reduces serum cortisol, …
Major (2)
- Azelastine Hydrochloride, Fluticasone Propionate + Alcohol— Central nervous system depressant; concurrent use should be avoided due to risk of somnolence and impairment of CNS perf…
- Azelastine Hydrochloride, Fluticasone Propionate + Ketoconazole— Strong CYP3A4 inhibitor that increases fluticasone propionate plasma exposure and reduces cortisol AUC. Caution should b…