Sepiapterin has 12 known drug interactions based on U.S. FDA drug labeling data. Of these, 8 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Methotrexate, Pemetrexed, Pralatrexate. Patients taking Sepiapterin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 12
- Contraindicated
- 8
- Moderate
- 4
Contraindicated (8)
- Sepiapterin + Methotrexate— DHFR inhibitor that may reduce sepiapterin metabolism to tetrahydrobiopterin (BH4). Avoid concomitant use.
- Sepiapterin + Pemetrexed— DHFR inhibitor that may reduce sepiapterin metabolism to tetrahydrobiopterin (BH4). Avoid concomitant use.
- Sepiapterin + Pralatrexate— DHFR inhibitor that may reduce sepiapterin metabolism to tetrahydrobiopterin (BH4). Avoid concomitant use.
- Sepiapterin + Raltitrexed— DHFR inhibitor that may reduce sepiapterin metabolism to tetrahydrobiopterin (BH4). Avoid concomitant use.
- Sepiapterin + Sulfamethoxazole— Sepiapterin reductase (SR) inhibitor that may reduce sepiapterin metabolism to BH4. Avoid concomitant use.
- Sepiapterin + Sulfasalazine— Sepiapterin reductase (SR) inhibitor that may reduce sepiapterin metabolism to BH4. Avoid concomitant use.
- Sepiapterin + Trimethoprim— DHFR inhibitor that may reduce sepiapterin metabolism to tetrahydrobiopterin (BH4). Avoid concomitant use.
- Sepiapterin + Trimetrexate— DHFR inhibitor that may reduce sepiapterin metabolism to tetrahydrobiopterin (BH4). Avoid concomitant use.
Moderate (4)
- Sepiapterin + Levodopa— Sepiapterin may increase tyrosine availability, a precursor of levodopa. Monitor patients for changes in neurologic stat…
- Sepiapterin + Sildenafil— PDE-5 inhibitor that with sepiapterin may cause additive vasorelaxation and blood pressure reduction. Monitor blood pres…
- Sepiapterin + Tadalafil— PDE-5 inhibitor that with sepiapterin may cause additive vasorelaxation and blood pressure reduction. Monitor blood pres…
- Sepiapterin + Vardenafil— PDE-5 inhibitor that with sepiapterin may cause additive vasorelaxation and blood pressure reduction. Monitor blood pres…