Does Sepiapterin Interact with Tadalafil?
CDI records a moderate classification for Sepiapterin and Tadalafil. The stored summary is: PDE-5 inhibitor that with sepiapterin may cause additive vasorelaxation and blood pressure reduction. Monitor blood pressure. The mechanism involves both drugs induce nitric oxide-mediated vasorelaxation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Tadalafil Class
- Phosphodiesterase 5 Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Both drugs induce nitric oxide-mediated vasorelaxation
What To Tell Your Doctor or Pharmacist
If you are taking Sepiapterin and your doctor is considering prescribing Tadalafil (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider