Does Sepiapterin Interact with Pemetrexed?
CDI records a contraindicated classification for Sepiapterin and Pemetrexed. The stored summary is: DHFR inhibitor that may reduce sepiapterin metabolism to tetrahydrobiopterin (BH4). Avoid concomitant use. The mechanism involves inhibition of dihydrofolate reductase reduces sepiapterin metabolism to bh4. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Pemetrexed Class
- Folate Analog Metabolic Inhibitor
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Inhibition of dihydrofolate reductase reduces sepiapterin metabolism to BH4
What To Tell Your Doctor or Pharmacist
If you are taking Sepiapterin and your doctor is considering prescribing Pemetrexed (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider