Dextroamphetamine Sulfate has 40 known drug interactions based on U.S. FDA drug labeling data. Of these, 7 are contraindicated combinations that should be avoided entirely. 19 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Furazolidone, Isocarboxazid, Mao Inhibitors. Patients taking Dextroamphetamine Sulfate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 40
- Contraindicated
- 7
- Major
- 19
- Moderate
- 12
Contraindicated (7)
- Dextroamphetamine Sulfate + Furazolidone— Metabolite slows amphetamine metabolism, potentiating effects with risk of hypertensive crisis and potentially fatal neu…
- Dextroamphetamine Sulfate + Isocarboxazid— MAOI concomitant use can cause hypertensive crisis with potentially fatal outcomes including stroke, myocardial infarcti…
- Dextroamphetamine Sulfate + Mao Inhibitors— Slow amphetamine metabolism, potentiating effects and increasing norepinephrine release. Can cause hypertensive crisis, …
- Dextroamphetamine Sulfate + Monoamine Oxidase Inhibitors (Maois)— Concomitant use can cause hypertensive crisis with potentially fatal outcomes including death, stroke, myocardial infarc…
- Dextroamphetamine Sulfate + Phenelzine— MAOI concomitant use can cause hypertensive crisis with potentially fatal outcomes including stroke, myocardial infarcti…
- Dextroamphetamine Sulfate + Selegiline— MAOI concomitant use can cause hypertensive crisis with potentially fatal outcomes including stroke, myocardial infarcti…
- Dextroamphetamine Sulfate + Tranylcypromine— MAOI concomitant use can cause hypertensive crisis with potentially fatal outcomes including stroke, myocardial infarcti…
Major (19)
- Dextroamphetamine Sulfate + Acetazolamide— Urinary alkalinizing agent increases blood levels and potentiates amphetamine action, increasing risk of adverse effects…
- Dextroamphetamine Sulfate + Buspirone— Serotonergic drug increasing risk of serotonin syndrome with dextroamphetamine sulfate.
- Dextroamphetamine Sulfate + Desipramine— Tricyclic antidepressant causing striking sustained increases in brain d-amphetamine concentration and potentiated cardi…
- Dextroamphetamine Sulfate + Duloxetine— SNRI concomitant use increases risk of serotonin syndrome. Monitor for signs and symptoms; discontinue if serotonin synd…
- Dextroamphetamine Sulfate + Fentanyl— Serotonergic drug increasing risk of serotonin syndrome with dextroamphetamine sulfate.
- Dextroamphetamine Sulfate + Fluoxetine— CYP2D6 inhibitor and serotonergic drug that increases dextroamphetamine exposure and risk of serotonin syndrome. Initiat…
- Dextroamphetamine Sulfate + Lithium— Serotonergic drug increasing risk of serotonin syndrome with dextroamphetamine sulfate.
- Dextroamphetamine Sulfate + Paroxetine— CYP2D6 inhibitor and serotonergic drug that increases dextroamphetamine exposure and risk of serotonin syndrome. Initiat…
- Dextroamphetamine Sulfate + Protriptyline— Tricyclic antidepressant causing striking sustained increases in brain d-amphetamine concentration and potentiated cardi…
- Dextroamphetamine Sulfate + Quinidine— CYP2D6 inhibitor that increases dextroamphetamine exposure and risk of serotonin syndrome. Initiate with lower doses and…
- Dextroamphetamine Sulfate + Ritonavir— CYP2D6 inhibitor that increases dextroamphetamine exposure and risk of serotonin syndrome. Initiate with lower doses and…
- Dextroamphetamine Sulfate + Selective Serotonin Reuptake Inhibitors (Ssri)— Concomitant use increases risk of serotonin syndrome. Initiate with lower doses and monitor for signs and symptoms.
- Dextroamphetamine Sulfate + Sertraline— SSRI concomitant use increases risk of serotonin syndrome. Monitor for signs and symptoms; discontinue if serotonin synd…
- Dextroamphetamine Sulfate + Sodium Bicarbonate— Gastrointestinal alkalinizing agent increases blood levels and potentiates amphetamine action. Concomitant use should be…
- Dextroamphetamine Sulfate + St. John'S Wort— Serotonergic drug increasing risk of serotonin syndrome with dextroamphetamine sulfate.
- Dextroamphetamine Sulfate + Tramadol— Serotonergic drug increasing risk of serotonin syndrome with dextroamphetamine sulfate.
- Dextroamphetamine Sulfate + Triptans— Serotonergic drugs that increase risk of serotonin syndrome with dextroamphetamine sulfate.
- Dextroamphetamine Sulfate + Tryptophan— Serotonergic drug increasing risk of serotonin syndrome with dextroamphetamine sulfate.
- Dextroamphetamine Sulfate + Venlafaxine— SNRI concomitant use increases risk of serotonin syndrome. Monitor for signs and symptoms; discontinue if serotonin synd…
Moderate (12)
- Dextroamphetamine Sulfate + Adrenergic Blockers— Amphetamines inhibit the effects of adrenergic blockers.
- Dextroamphetamine Sulfate + Ammonium Chloride— Urinary acidifying agent that increases ionized amphetamine species, increasing urinary excretion and lowering blood lev…
- Dextroamphetamine Sulfate + Antihistamines— Amphetamines may counteract the sedative effects of antihistamines.
- Dextroamphetamine Sulfate + Ascorbic Acid— Gastrointestinal acidifying agent that lowers amphetamine absorption and blood levels.
- Dextroamphetamine Sulfate + Fruit Juice— Gastrointestinal acidifying agent lowers amphetamine absorption, reducing blood levels and efficacy.
- Dextroamphetamine Sulfate + Glutamic Acid Hcl— Gastrointestinal acidifying agent that lowers amphetamine absorption and blood levels.
- Dextroamphetamine Sulfate + Guanethidine— Gastrointestinal acidifying agent that lowers amphetamine absorption and blood levels.
- Dextroamphetamine Sulfate + Methenamine Salts— Urinary acidifying agent that lowers blood levels and efficacy of amphetamines. Dose adjustment may be needed based on c…
- Dextroamphetamine Sulfate + Reserpine— Gastrointestinal acidifying agent that lowers amphetamine absorption and blood levels.
- Dextroamphetamine Sulfate + Sodium Acid Phosphate— Urinary acidifying agent that increases ionized amphetamine species, increasing urinary excretion and lowering blood lev…
- Dextroamphetamine Sulfate + Sodium Chloride, Sodium Lactate, Potassium Chloride, Calcium Chloride And Dextrose Monohydrate— Renal clearance of alkaline dextroamphetamine may be decreased due to alkalinizing action of lactate.
- Dextroamphetamine Sulfate + Thiazides— Some thiazides act as urinary alkalinizing agents, decreasing urinary excretion and potentiating amphetamine effects.