Does Dextroamphetamine Sulfate Interact with Isocarboxazid?
CDI records a contraindicated classification for Dextroamphetamine Sulfate and Isocarboxazid. The stored summary is: MAOI concomitant use can cause hypertensive crisis with potentially fatal outcomes including stroke, myocardial infarction, and aortic dissection. Do not use concurrently or within 14 days after discontinuing. The mechanism involves mao inhibition combined with amphetamine sympathomimetic effects causes hypertensive crisis. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
MAO inhibition combined with amphetamine sympathomimetic effects causes hypertensive crisis
What To Tell Your Doctor or Pharmacist
If you are taking Dextroamphetamine Sulfate and your doctor is considering prescribing Isocarboxazid (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider