Home›Dextroamphetamine Sulfate›Dextroamphetamine Sulfate + Selegiline

Does Dextroamphetamine Sulfate Interact with Selegiline?

Dextroamphetamine Sulfate and Selegiline have a contraindicated drug interaction according to U.S. FDA drug labeling data. MAOI concomitant use can cause hypertensive crisis with potentially fatal outcomes including stroke, myocardial infarction, and aortic dissection. Do not use concurrently or within 14 days after discontinuing. The mechanism involves mao inhibition combined with amphetamine sympathomimetic effects causes hypertensive crisis. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Selegiline Class
Monoamine Oxidase Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Dextroamphetamine Sulfate and Selegiline occurs because mao inhibition combined with amphetamine sympathomimetic effects causes hypertensive crisis. Clinically, this means maoi concomitant use can cause hypertensive crisis with potentially fatal outcomes including stroke, myocardial infarction, and aortic dissection. do not use concurrently or within 14 days after discontinuing. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Dextroamphetamine Sulfate and your doctor is considering prescribing Selegiline (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Dextroamphetamine Sulfate(Dextroamphetamine Sulfate)+💊 Selegiline(Emsam)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Monoamine Oxidase Inhibitor
Source
NLP:dextroamphetamine sulfate

What this means in plain English

MAOI concomitant use can cause hypertensive crisis with potentially fatal outcomes including stroke, myocardial infarction, and aortic dissection. Do not use concurrently or within 14 days after discontinuing.

What the FDA label says

"MAO inhibition combined with amphetamine sympathomimetic effects causes hypertensive crisis"

📖 Source: NLP:dextroamphetamine sulfate

Share this result:XFacebookWhatsAppReddit
Add more drugs
Check Dextroamphetamine Sulfate and Selegiline against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.