Diclofenac has 18 known drug interactions based on U.S. FDA drug labeling data. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetylsalicylic Acid, Angiotensin Ii, Cyclosporine. Patients taking Diclofenac should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 18
- Major
- 7
- Moderate
- 9
- Minor
- 1
Major (7)
- Diclofenac + Acetylsalicylic Acid— Concomitant use associated with significantly increased incidence of GI adverse reactions and increased risk of bleeding…
- Diclofenac + Angiotensin Ii— May diminish antihypertensive effect and result in renal function deterioration in vulnerable patients.
- Diclofenac + Cyclosporine— When coadministered with cyclosporine in rheumatoid arthritis patients, the AUC of diclofenac was significantly increase…
- Diclofenac + Deferiprone— UGT1A6 inhibitor; avoid co-administration with FERRIPROX.
- Diclofenac + Mao Inhibitors— Concomitant use may result in deterioration of renal function and acute renal failure, especially in elderly, volume-dep…
- Diclofenac + Pemetrexed— Concomitant use may increase risk of pemetrexed-associated myelosuppression, renal, and GI toxicity.
- Diclofenac + Warfarin— Synergistic effect on bleeding with increased risk of serious bleeding compared to either drug alone.
Moderate (9)
- Diclofenac + Andthiazide— NSAIDs can reduce natriuretic effect; monitor patients to assure diuretic efficacy including antihypertensive effects.
- Diclofenac + Digoxin— Increases digoxin concentrations; magnitude unclear. Requires monitoring and dose adjustment.
- Diclofenac + Diuretics— Monitor for signs of worsening renal function and diuretic efficacy including antihypertensive effects.
- Diclofenac + Furosemide— In such high-risk patients, monitor for signs of worsening renal function ( 7 ) Diuretics: NSAIDs can reduce natriuretic…
- Diclofenac + Lithium— Monitor patients for signs of lithium toxicity during concomitant use.
- Diclofenac + Methotrexate— Monitor patients for methotrexate toxicity during concomitant use.
- Diclofenac + Nonselective Beta-Adrenergic Antagonists— Concomitant use requires adequate hydration and renal function assessment at beginning of treatment.
- Diclofenac + Propranolol— NSAIDs may diminish the antihypertensive effect of beta-blockers. Risk of renal function deterioration in elderly, volum…
- Diclofenac + Selective Serotonin Reuptake Inhibitors (Ssri)— Monitor for signs of bleeding with concomitant use of diclofenac and SSRIs due to increased bleeding risk.
Minor (1)
- Diclofenac + Misoprostol— Misoprostol has no clinically significant effect on the kinetics of diclofenac.