Diclofenac has 18 known drug interactions based on U.S. FDA drug labeling data. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Angiotensin Ii, Aspirin, Cyclosporine. Patients taking Diclofenac should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 18
- Major
- 7
- Moderate
- 9
- Minor
- 1
Major (7)
- Diclofenac + Angiotensin Ii— May diminish antihypertensive effect and result in renal function deterioration in vulnerable patients.
- Diclofenac + Aspirin— Concomitant use associated with significantly increased incidence of GI adverse reactions and increased risk of bleeding…
- Diclofenac + Cyclosporine— When coadministered with cyclosporine in rheumatoid arthritis patients, the AUC of diclofenac was significantly increase…
- Diclofenac + Deferiprone— UGT1A6 inhibitor; avoid co-administration with FERRIPROX.
- Diclofenac + Mao Inhibitors— Concomitant use may result in deterioration of renal function and acute renal failure, especially in elderly, volume-dep…
- Diclofenac + Pemetrexed— Concomitant use may increase risk of pemetrexed-associated myelosuppression, renal, and GI toxicity.
- Diclofenac + Warfarin— Synergistic effect on bleeding with increased risk of serious bleeding compared to either drug alone.
Moderate (9)
- Diclofenac + Andthiazide— NSAIDs can reduce natriuretic effect; monitor patients to assure diuretic efficacy including antihypertensive effects.
- Diclofenac + Digoxin— Increases digoxin concentrations; magnitude unclear. Requires monitoring and dose adjustment.
- Diclofenac + Diuretics— Monitor for signs of worsening renal function and diuretic efficacy including antihypertensive effects.
- Diclofenac + Furosemide— In such high-risk patients, monitor for signs of worsening renal function ( 7 ) Diuretics: NSAIDs can reduce natriuretic…
- Diclofenac + Lithium— Monitor patients for signs of lithium toxicity during concomitant use.
- Diclofenac + Methotrexate— Monitor patients for methotrexate toxicity during concomitant use.
- Diclofenac + Nonselective Beta-Adrenergic Antagonists— Concomitant use requires adequate hydration and renal function assessment at beginning of treatment.
- Diclofenac + Propranolol— NSAIDs may diminish the antihypertensive effect of beta-blockers. Risk of renal function deterioration in elderly, volum…
- Diclofenac + Selective Serotonin Reuptake Inhibitors (Ssri)— Monitor for signs of bleeding with concomitant use of diclofenac and SSRIs due to increased bleeding risk.
Minor (1)
- Diclofenac + Misoprostol— Misoprostol has no clinically significant effect on the kinetics of diclofenac.