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Does Diclofenac Interact with Lithium?

Diclofenac and Lithium have a moderate drug interaction according to U.S. FDA drug labeling data. Monitor patients for signs of lithium toxicity during concomitant use. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity: Moderate
Diclofenac Class: Nonsteroidal Anti-inflammatory Drug
Management: Monitor for effects
Data Source: U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Diclofenac and your doctor is considering prescribing Lithium (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Ask whether any dosage adjustments are needed
Never stop or change either medication without first consulting your healthcare provider

💊 Diclofenac(Diclofenac Sodium)+💊 Lithium(Lithium)

Severity & Interaction Details

🟡

moderate

Be aware — moderate interaction

Documented interaction with manageable risk. May require dose adjustment or monitoring.

Severity scale

MinorContra

On record

Yes

Drug A class

Nonsteroidal Anti-inflammatory Drug

Drug B class

—

Source

NLP:diclofenac

What this means in plain English

Monitor patients for signs of lithium toxicity during concomitant use.

About Diclofenac and Lithium

Diclofenac is a Nonsteroidal Anti-inflammatory Drug. Diclofenac is applied to the skin, whereas Lithium is taken by mouth. Both Diclofenac and Lithium carry an FDA boxed warning — the agency's most serious safety designation.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.