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Does Diclofenac Interact with Misoprostol?

Diclofenac and Misoprostol have a minor drug interaction according to U.S. FDA drug labeling data. Misoprostol has no clinically significant effect on the kinetics of diclofenac. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Minor
Diclofenac Class
Nonsteroidal Anti-inflammatory Drug
Misoprostol Class
Prostaglandin E1 Analog
Management
Generally manageable
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Diclofenac and your doctor is considering prescribing Misoprostol (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Diclofenac(Diclofenac Sodium)+💊 Misoprostol(Cytotec)

Severity & Interaction Details

✅
minor
Generally safe — minor interaction
Low clinical significance. Routine awareness is usually sufficient.
Severity scale
MinorContra
On record
Yes
Drug A class
Nonsteroidal Anti-inflammatory Drug
Drug B class
Prostaglandin E1 Analog
Source
NLP:misoprostol

What this means in plain English

Misoprostol has no clinically significant effect on the kinetics of diclofenac.

About Diclofenac and Misoprostol

Diclofenac is a Nonsteroidal Anti-inflammatory Drug, while Misoprostol is a Prostaglandin E1 Analog. Misoprostol is also sold under the brand name Cytotec. Diclofenac is applied to the skin, whereas Misoprostol is taken by mouth. Both Diclofenac and Misoprostol carry an FDA boxed warning — the agency's most serious safety designation.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.